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hbiostat.org | ||
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www.fharrell.com
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| | | | | Observational data from electronic health records may contain biases that large sample sizes do not overcome. Moderate confounding by indication may render an infinitely large observational study less useful than a small randomized trial for estimating relative treatment effectiveness. | |
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errorstatistics.com
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| | | | | Stephen Senn Head of Competence Center for Methodology and Statistics (CCMS) Luxembourg Institute of Health Twitter @stephensenn Being a statistician means never having to say you are certain A recent discussion of randomised controlled trials[1] by Angus Deaton and Nancy Cartwright (D&C) contains much interesting analysis but also, in my opinion, does not escape rehashing... | |
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www.rdatagen.net
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| | | | | An investigator I frequently consult with seeks to estimate the effect of a palliative care treatment protocol for patients nearing end-stage disease, compared to a more standard, though potentially overly burdensome, therapeutic approach. Ideally, we would conduct a two-arm randomized clinical trial (RCT) to create comparable groups and obtain an unbiased estimate of the intervention effect. However, in this case, it may be considered unethical to randomize patients to a non-standard protocol. | |
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poissonisfish.com
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| | | Someof the most fundamental functions in R, in my opinion, are those that deal with probability distributions. Whenever you compute a P-value you relyon a probability distribution, and there are many types out there. In this exercise I will cover four: Bernoulli, Binomial, Poisson, and Normal distributions. Let me begin with some theory first: Bernoulli... | ||