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fharrell.com | ||
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www.rdatagen.net
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| | | | | An investigator I frequently consult with seeks to estimate the effect of a palliative care treatment protocol for patients nearing end-stage disease, compared to a more standard, though potentially overly burdensome, therapeutic approach. Ideally, we would conduct a two-arm randomized clinical trial (RCT) to create comparable groups and obtain an unbiased estimate of the intervention effect. However, in this case, it may be considered unethical to randomize patients to a non-standard protocol. | |
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www.fharrell.com
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| | | | | Observational data from electronic health records may contain biases that large sample sizes do not overcome. Moderate confounding by indication may render an infinitely large observational study less useful than a small randomized trial for estimating relative treatment effectiveness. | |
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f1000research.com
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| | | | | Read the original article in full on F1000Research: Does evidence support the high expectations placed in precision medicine? A bibliographic review | |
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www.harding.edu
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| | | Explore our diverse undergraduate programs. Learn about our majors, faculty and resources designed to support your academic journey. | ||
