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www.fharrell.com | ||
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hbiostat.org
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| | | | | Randomized clinical trials are successful because they do not mimic clinical practice. They remain highly clinically relevant despite this. | |
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fharrell.com
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| | | | | This article shows an example formally testing for heterogeneity of treatment effect in the GUSTO-I trial, shows how to use penalized estimation to obtain patient-specific efficacy, and studies variation across patients in three measures of treatment effect. | |
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fharrell.com
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| | | | | This article provides my reflections after the PCORI/PACE Evidence and the Individual Patient meeting on 2018-05-31. The discussion includes a high-level view of heterogeneity of treatment effect in optimizing treatment for individual patients. | |
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jaydaigle.net
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| | | This is the second-part of a three-part series on hypothesis testing. Today we'll look at the way we do hypothesis testing in practice, and how it tends to fail. Modern researchers use hypothesis testing as a tool to develop knowledge, but it's really a tool for making decisions, and so it encourages us to draw strong conclusions from weak evidence. It also encourages us to view studies that don't reject the null hypothesis as failures, which leads even honest and dedicated researchers to do shoddy resea... | ||
