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digitalcommons.fiu.edu | ||
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digitalcommons.wustl.edu
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| | | | | BACKGROUNDS: While many studies agree that consanguinity increases the rate of congenital heart disease (CHD), few genome analyses have been conducted with consanguineous CHD cohorts. METHODS: We recruited 73 CHD probands from consanguineous families in Turkey and used whole-exome sequencing (WES) to identify genetic lesions in these patients. RESULTS: On average, each patient had 6.95 rare damaging homozygous variants, 0.68 of which are loss-of-function (LoF) variants. Seven patients (9.6%) carried damaging homozygous variants in five causal CHD genes. Six of those patients exhibited laterality defects (six HTX and one D-TGA). Three additional patients (4.1%) harbored other types of CHD-associated genomic alterations, which overall explained 13.7% (10/73) o... | |
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digitalcommons.wayne.edu
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| | | | | Recommendations to expand Cohen's (1988) rules of thumb for interpreting effect sizes are given to include very small, very large, and huge effect sizes. The reasons for the expansion, and implications for designing Monte Carlo studies, are discussed. | |
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scholar.valpo.edu
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| | | | | A popular meme depict Galadriel and Frodo admitting that Sauron is "weirdly sexy," a humorous allusion to The Rings of Power's Halbrand. The show's controversial revelation of Halbrand as Sauron highlights the differences between Tolkien's construction of Second and Third Age Sauron as an attractive or admirable leader compared to Peter Jackson's portrayal of him as a monster or disembodied fiery eyeball. This, in turn, has implications for the geopolitical order of Middle-earth in which many people legi... | |
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dc.swosu.edu
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| | | Wise speculates on the involvement of J.R.R. Tolkien in the group nomination of E.M Forster for the Nobel Prize in Literature in 1954; he discusses not only the politics behind the nomination but reads Forster's Howards End and A Passage to India in the light of the tension between Tolkien's interests in nationalism and inter-racial cooperation. | ||
