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www.plengegen.com
| | www.wired.com
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| | In a small study, researchers modified patients' immune cells to target their particular cancer-but it only worked for a third of volunteers.
| | brixtonblog.com
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| | With lockdowns impacting us all, it can sometimes be easy to forget other issues that still exist in the world. However, there are thousands of people in hospital relying on blood donations to survive, and they need your help. In the UK, 15,000 people suffer from sickle cell disease and more than 30...
| | www.oxfordstudent.com
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| | Learn how CASGEVY, the first NHS-approved CRISPR gene therapy, treats sickle cell disease through a revolutionary genetic editing technique.
| | fharrell.com
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| Historical data (HD) are being used increasingly in Bayesian analyses when it is difficult to randomize enough patients to study effectiveness of a treatment. Such analyses summarize observational studies' posterior effectiveness distribution (for two-arm HD) or standard-of-care outcome distribution (for one-arm HD) then turn that into a prior distribution for an RCT. The prior distribution is then flattened somewhat to discount the HD. Since Bayesian modeling makes it easy to fit multiple models at once...